Welcome to UltraFucoidan™
Natural Immune Support from the Ocean
The Nature’s Potency in Every Granule.
Elevate Your Creations with Pure Wellness.
Not Just a Product – It’s an Ingredient Revolution!
The Nature’s Potency in Every Granule.
Elevate Your Creations with Pure Wellness.
Not Just a Product – It’s an Ingredient Revolution!
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Why Do We Need Fucoidan?
Fucoidan helps protect your cells from damage caused by harmful molecules called free radicals. This can lower the risk of diseases like cancer and heart disease.
Fucoidan boosts your immune system by making your immune cells more active. This helps your body fight off infections and stay healthy.
Fucoidan lowers the levels of fat and cholesterol in your blood. It stops your body from absorbing too much fat from food and helps remove cholesterol, reducing the risk of heart disease.
Fucoidan helps wounds heal faster by encouraging cell growth and collagen production, which are important for repairing tissue. It also reduces swelling and inflammation.
Fucoidan helps you recover faster from illnesses by boosting your immune system and reducing inflammation. It makes your body better at fighting off infections and healing itself.
Fucoidan protects your stomach by forming a barrier on the stomach lining. This prevents damage from stomach acid and reduces inflammation, helping prevent and heal stomach ulcers.
Why UltraFucoidan™
UltraFucoidan™ is a highly bioactive compound isolated from the Laminaria and Undaria species grown in Korean ocean waters. Our proprietary manufacturing technologies allow us to maximize the sulfate content, at over 25% with maximum bioactivity, to optimize therapeutic properties. This process is:
In addition, the fucoidan extracts are combined with rich polyphenol antioxidants for additional immunity support. The applications are endless for pharmaceutical, nutritional, dermatological, and medical device applications.
What is Fucoidan?
- A complex sulfated polysaccharide found in brown algae and seaweed.
- Rich in macronutrients, L-fucose, monosaccharides, uronic acids, acetyl groups, and protein.
- Supports immune, cardiovascular, skin, and digestive health.
Figure 1 shows the basic structure of algal polysaccharides, specifically highlighting the sulfated (1→3)-linked fucose backbone typical of fucoidan from Undaria pinnatifida, used in UltraFucoidan™ by Vesta Ingredients. The Fucp refers to L-fucopyranose. In fucoidan, these Fucp units are typically linked via the (1→3) glycosidic bonds. In the case of Undaria pinnatifida, they are HEAVILY SULFATED, meaning many hydroxyl groups on the fucose ring are replaced with sulfate groups, CONTRIBUTING TO ITS BIOLOGICAL ACTIVITY.
Fucoidan is known for its abundance of macronutrients and health benefits. Fucoidan is a complex sulfated polysaccharide large molecule found in the cell-wall matrix of brown algae and seaweed, and contains high amounts of L-fucose.
Fucoidan contains various monosaccharides (mannose, galactose, glucose, xylose, etc.), uronic acids, acetyl groups, and protein.
With these abundant organic compounds, Fucoidan supports immune, cardiovascular, skin, and digestive health.
Fucoidan is in a family of brown algae sulphated polysaccharides whose main polyfucose sugar unit is sulfated fucose. The basic structure of the algal polysaccharides is shown in Figure 1. The reader can easily see the presence of multiple sulfated groups in the fucoidan species. The fucoidan order Laminariales, sp. Undaria pinnatifida is distinct with the completely sulfated (1→3)-linked Fucp backbone structure for UltraFucoidan™ by Vesta Ingredients.
The high sulfate content of UltraFucoidan™ is the basis of the health benefits of the fucoidan extract. Additional information is presented in this document regarding the health benefits of UltraFucoidan™.
The fucoidan seaweed extract of UltraFucoidan™ has been studied as a novel source of a variety of compounds reported to possess biological activity of potential medicinal value and for compounds considered to be a rich source of antioxidants. These natural antioxidants have been used for centuries and are naturally found in plant materials. Fucoidan is safe for consumers because of the natural source of the plant material.
Fucoidan exhibits a wide range of biological activity summarized below (Varinska et al., 2017):
- anti-inflammatory
- anti-viral
- anti-tumor
- anti-thrombotic
- anti-angiogenic
UltraFucoidan is unique and has the most advantages. The main feature of UltraFucoidan is the higher concentration of sulfur and actual Fucoidan than most other products already on the market. This feature results in the highest concentration of antioxidant compounds for the strongest bioactivity. UltraFucoidan has an abundant 15% sulfur with 85% fucoidan for the most benefit.
In addition, the source of Vesta’s UltraFucoidan derives from the Laminaria and Undaria species grown in Korean ocean waters, which are considered an enriched and natural body of clean, unpolluted water.
Undaria Pinnatifida
Undaria pinnatifida, commonly known as wakame, is a type of brown seaweed that typically grows in coastal waters up to 20 meters deep. It thrives in sheltered reef areas where factors like temperature, nutrients, light, and depth are crucial for its growth. Undaria can grow up to 2 meters in length within a year, making it a rapidly renewable resource.
As a source of fucoidan, Undaria pinnatifida stands out among other seaweed species because it contains high levels of this beneficial compound. Fucoidan is known for its potential health benefits, including anti-inflammatory, antiviral, and anticancer properties. Undaria’s high fucoidan content, combined with its rapid growth and nutrient-rich profile, makes it a valuable seaweed compared to other species.
Laminaria
Laminaria seaweed, also known as kelp, is a large brown algae that grows in cold ocean waters and forms dense underwater forests. It has a holdfast to anchor it, a stem-like stipe, and long fronds that help it thrive. Laminaria is very nutritious, containing iodine, potassium, calcium, and various vitamins.
Laminaria is special because it has a lot of fucoidan, a compound with potential health benefits like reducing inflammation and fighting viruses. It stands out from other seaweeds due to its high nutritional value and significant fucoidan content.
Fucoidan containing foods such as seaweed are known in the traditions and history of many Asian countries as a staple in their diets which accounts for the health benefits leading to longer life. It wasn’t until the past several decades that biomedical research has extensively studied the effects and benefits of Fucoidan.
Several studies have established the mechanisms by which Fucoidan is utilized by the body to generate vital hormones and enzymes, and these studies have elucidated the role of fucoidan in helping to improve immune, cardiovascular, skin, and digestive health.
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Research & Development
Vesta Nutra has conducted extensive research on fucoidan, a compound found in seaweed known for its numerous health benefits. Fucoidan is rich in antioxidants, which help protect the body from damage caused by free radicals. This compound supports immunity and has shown promising potential in cancer treatment, exhibiting strong anti-cancer properties.
In addition to our own research, there are multiple global leading research institutions that are conducting human clinical trials. The research aims to further understand and validate the health benefits of fucoidan.
Research on Health Benefits of UltraFucoidan™
Fucoidan has many antioxidants, which help protect your body from damage. It contains chemicals called polyphenols found in seaweed. A special kind of polyphenol called phlorotannins is only found in brown seaweeds.
Free radicals are unstable molecules that can harm your cells, and they are a normal part of life. Oxygen, which we need to live, can create these free radicals. They are also produced when we have active lifestyles, like playing sports and exercising. Other factors like smoking, drinking alcohol, and inflammation can also create free radicals. We can’t avoid them, and the more we live, the more we encounter them (Health supplements from antioxidant-rich seaweed | Research and Innovation (europa.eu)).
Antioxidants help recycle glutathione and reactivate used antioxidants. Fucoidan helps remove free radicals and reduce oxidative damage, making it a great antioxidant. It is also rich in essential amino acids, vegetable protein, vitamins (especially vitamin B-12), minerals, and antioxidants, which are all good for your health (Seaweed provides vitamins, minerals and antioxidants – San Diego Union-Tribune (sandiegouniontribune.com)).
In addition to this, human studies have shown that fucoidans can slow down how quickly our bodies absorb sugar after eating. This could help manage blood sugar levels and prevent spikes after meals (Lu & Chen, 2022). These findings suggest that seaweed could be a very healthy addition to our diet.
Figure 1. Injured liver cells (left), and Fucoidan-protected liver cells (right) (Cho et al., 2015).
Fucoidan has been studied a lot in cancer research. Many studies have shown that fucoidan has properties that can help stop the growth of blood vessels in tumors (anti-angiogenic) and reduce tumor growth (anti-tumorigenic). Fucoidan’s high sulfate content supports these anti-cancer properties. The anti-angiogenic effect means it can stop tumors from developing new blood vessels, which is due to a decrease in NFκB expression, an important factor for VEGF expression. Fucoidan also inhibits AKT, which is involved in ERK phosphorylation and ERBB signaling in melanoma (Thakur et al., 2017).
In melanoma, which relies on ERBB signaling, tumor growth was reduced by 85% when fucoidan from New Zealand U. pinnatifida was used with lapatinib treatment. Fucoidan not only stops tumor growth but also reduces the side effects of prolonged lapatinib treatment and doubles its cell-killing ability. This is linked to the decrease in AKT and NFκB signaling, crucial for melanoma cell survival. Fucoidan enhances the effects of lapatinib by inhibiting ERBB3, a key receptor in melanoma, making it a potent addition to melanoma treatment (Thakur et al., 2017).
The strong anti-angiogenic activity of fucoidan comes from its diverse composition, including fucose, xylose, galactose, mannose, glucuronic acid, and sulfate. The activity increases when sulfate groups attach to these sugars. Fucoidan also boosts antioxidant defense, protecting cells and reducing aging-related stress (Cong et al., 2016).
Fucoidan protects liver cells from bile acid-induced damage and inhibits the invasion of hepatocellular carcinoma (HCC). The photos in Figure 1 show injured liver cells on the left and healthy, fucoidan-protected cells on the right (Cho et al., 2015). It also helps treat metastatic HCC by down-regulating ID-1, which decreases the invasion of HCC cells significantly (Cho et al., 2016).
Targeting calcium signaling with fucoidan might also help fight tumors. Fucoidan affects Ca2+ responses and might inhibit different G-protein coupled receptors linked with Ca2+ function (Wu et al., 2018). By blocking Ca2+ influx into cells and T-type calcium channels, fucoidan can affect cell cycle progression and cell proliferation, inhibiting human cancer cell growth. Fucoidan and calcium channel blockers are potential treatments for tumors that depend on T-type calcium channels to grow (Wu et al., 2018).
Product Details
- Appearance: Fine Powder
- Odor / Taste: Characteristic
- Activity: 85%
- Package Unit: 1-5 kg
- Store in a cool, dry place
- Do not freeze
- Keep away from direct sunlight
- Packaging: Aluminum Foil Bags, 1-5 kg
- Capsules
- Tablet
- Chews
- Fine Chemicals
- Gummies & Pectin
- Dry Mixes
- Drinks/Juices
- Bars
- Cosmetics
Abundance
Abundance
Ultrafiltration
Ultrafiltration
The proprietary manufacturing method of Vesta UltraFucoidan™ utilizes an Alcohol-Free method and results in a very pure and highly stable product. The UltraFucoidan™ product is all natural and is produced without solvents and is extracted with clean water.
Safety
Safety
In addition, the source for Vesta UltraFucoidan™ is from an ocean in Korea which is known to be isolated from Japanese nuclear contamination and hazards.
Bioactivity
Uses & Applications
References
A study of fucoidan from the brown seaweed Chorda filum
Alexander O. Chizhov a,b, Anne Dell a, Howard R. Morris a, Stuart M. Haslam a,
Roy A. McDowell a, Alexander S. Shashkov b, Nikolay E.
Fucoidan as a Potential Therapeutic for Major Blinding Diseases—A Hypothesis
Alexa Klettner
Department of Ophthalmology, University Medical Center, University of Kiel, 24105 Kiel, Germany;
aklettner@auge.uni-kiel.de; Tel.: +0049-431-597-2401; Fax: +0049-431-597-3140
Fucoidan: Structure and Bioactivity
Bo Li*, Fei Lu, Xinjun Wei and Ruixiang Zhao
School of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, Henan, P.R.
China.
Therapies from Fucoidan: An Update
Janet Helen Fitton *, Damien N. Stringer and Samuel S. Karpiniec
Fucoidans are a class of sulfated fucose-rich polysaccharides found in brown
marine algae and echinoderms. Fucoidans have an attractive array of bioactivities and
potential applications including immune modulation, cancer inhibition, and pathogen
inhibition….
And,
- Ale et al. 2011. Important Determinants for Fucoidan Bioactivity- A Critical Review of Structure-Function Relations. Marine Drugs. 9, 2106-2130.
- Fu et al. 2016. Extraction of phenolic antioxidants from four selected seaweeds obtained. International Food Research Journal. 236, 2363-2369
- Cho et al. 2015. Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating. Acta Pharmaceutic.
- Hsu et al. 2017. Fucoidan induces Toll-like receptor 4-regulated reactive oxygen species and promotes endoplasmic reticulum stress-mediated apoptosis in lung. Sci Rep. 7, 44990.
- Hurd et al. 2023. From Tasmania to the world-long and strong traditions in seaweed use, research, and development. Botanica Marina. vol. 66, no. 1, pp. 1-36.
- Jin et al. 2021. The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles. Marine Drugs 19, no. 5: 265.
- Kim et al. 2017. HT-29 Cell Death And Cell Cycle Following Fucoidan Treatment. Molecular Medicine Reports 15. 4116-4122.
- Lu and Chen. 2022. Seaweeds as Ingredients to Lower Glycemic Potency of Cereal Foods Synergistically—A Perspective. Foods 11, no. 5: 714.
- Saetan et al. 2021. Potential health benefits of fucoidan from the brown seaweeds Sargassum Plagiophyllum and sargassum polycystum. Journal of Applied Phycology, 33(5), 3357–3364.
- Senthilkumar et al. 2013. Brown seaweed fucoidan- biological activity and apoptosis, growth signaling mechanism in cancer. International Journal of Biological Macromolecules. ScienceDirect. 60,366-74.
- Thakur et al. 2017. The natural compound fucoidan from New Zealand Undaria pinnatifida synergizes with the ERBB
- Tsai et al. 2017. Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer. Marine Drugs. 15, 122.
- Varinska et al. 2017. Angiomodulators in cancer therapy- New perspectives. BiomedPharmacotherapy 89, 578-590.
- Wang et al. 2017. Effect of Fucoidan on B16 Murine Melanoma Cell Melanin Formation and Apoptosis. Afr J Tradit Complement Altern Med. 14 (4)149-155.
- Wu et al. 2018. Fucoidan inhibits Ca2+ responses induced by a wide spectrum of agonists. Molecular Medicine Reports, 17(1), 1428–1436.
- Xu et al. 2017. Recent Advances in Marine Algae Polysaccharides- Isolation, Structure, and Activities. Marine Drugs. 15(12) 388.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. This information on this website is provided for developmental purposes only. This is not a specification, a guarantee of composition, or certificate of analysis. The information contained herein is correct to the best of our knowledge. Recommendations and suggestions contained on this website are made without guarantee or representation as to results. We suggest you evaluate these recommendations prior to use. Our responsibility for claims arising from breach of warranty, negligence, or otherwise is limited to the purchase price of the material.