MK7

Promoting Bone and Cardiovascular Health

Natto MK-7™

Promoting Bone and Cardiovascular Health

Vesta’s Natto MK-7™ (Vitamin K2: MK-7) is an all-natural product and is highly bioavailable.

Vitamin K is essential for proper bone mineralization and in regulating calcium levels within arteries. It has gained increased attention due to its highly efficacious fibrinolytic enzyme properties.

Why Natto MK-7™?

  • 100% Natural Vitamin K2 (MK7 from Natto)
  • 100% Trans-form
  • Highly Stable & Highly Bioavailable

  • No Solvents/Additives/ Preservatives, nonGMO

  • Free of Allergens
  • Clinically-proven to support bone & cardiovascular health

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  • All-natural produced MK‑7 results in high-yield, high‑quality, highly‑bioavailable, and highly‑effective finished product.

  • Natto MK‑7™ helps to regulate calcium levels in bones and arteries.

  • Vitamin K2 MK‑7 has the highest bioavailability and bioactivity of all Vitamin K vitamers.

  • Supports both circulatory and skeletal health.

  • New manufacturing process using CO2 and no solvents

  • Supercritical (CO2) extraction for a concentrated and pure extract that is environmentally friendly.

  • Clean purification with separation of MK‑7 trans form.

  • Complies with USP 40 Monographs.

  • Supercritical (CO2) extraction with high pressure and low temperature, for an environmentally friendly manufacturing process
  • Preserves the original active properties without any solvents for the most bioactive compound
  • Produces a concentrated and pure extract that is very stable and highly bioavailable

How does MK-7 support healthy bones?

Bone mineral density is directly related to the amount of MK-7 that is present within the body. With the addition of MK-7 to the diet, aging-related bone loss might be avoided, and support is provided for skeletal health.

Benefits of Natto MK-7™

MK-7 is unique in that it displays no toxicity at normal recommended levels, and unlike Vitamin K2, it does not concentrate in the liver. MK-7 helps promote a healthy cardiovascular system and may help to maintain healthy bones, joints, and arteries.

Why is MK-7 Vitamin K2 Necessary?

MK-7 regulates calcium through an amino acid that is part of the matrix GLA protein (a calcium-regulating protein), which is dependent on MK-7 to function properly. If the protein does not contain enough MK-7, it will not be able to retain calcium through carboxylation. Without MK-7, the calcium does not get directed to the areas where it is needed, such as the bones and instead, calcium moves out into the bloodstream and deposits in arteries and other soft tissue. MK-7 ensures that the calcium is directed and retained in the bones at normal, healthy levels.

Health Benefits

 

A team of medical doctors looked at 53 patients with hemodialysis deficiencies and severe arterial calcification. They supplemented these patients daily with 135µg and 360µg Vitamin K2 and found remarkable improvements. They found significantly lower levels of inactive MGP, and more importantly, decreased calcification of patients’ arteries.

Post-menopausal women often have problems with coronary calcification. In a study conducted in Europe, scientists observed 564 post-menopausal women and found a direct relationship between VitaminK2 consumption and reduced coronary calcification. The authors propose Vitamin K2 as an important preventative solution for cardiovascular disease.

A large research study looked at 4807 human subjects over the course of 7-10 years and observed the risk of Coronary Heart Disease with respect to Vitamin K2 intake. After taking into consideration variable factors, they found an inverse relation in Vitamin K2 intake and CHD. They conclude with, “These findings suggest that an adequate intake of menaquinone (Vitamin K2) could be important for CHD prevention.”

 

Bone Health

Our body structure

Though our bones may seem static, our skeletal system is very much alive and constantly reshaping. In our bones, there are continuous opposing forces of bone deconstruction and bone reconstruction that contribute to this dynamic reshaping process. Two major cells contribute to this: osteoblasts (cells that build bone) and osteoclasts (cells that break down bone). As osteoblasts continually incorporate calcium to build bone matrix and osteoclasts break down bone, both cell types are regulated by only a handful of proteins: GLA protein, S protein, and Osteocalcin. The activity of all three of these proteins is dependent on Vitamin K2. Vitamin K2 modifies the proteins to cause osteoblast activation and osteoclast inhibition. This, in turn, implies calcium incorporation into the bone matrix to improve bone strength. When this balance of bone matrix construction and deconstruction is disrupted towards deconstruction, weakening of the bones (osteoporosis) occurs, and various health complications can arise.

Osteoporosis is a disease in which the weakening of the bones causes an increased risk of fracture. Poor diet, aging, low body weight, low levels of sex hormones (menopause), smoking, and some medications can increase the risk for osteoporosis. According to the Centers for Disease Control (CDC), Osteoporosis affects over 5.3 million men and women over the age of 50 in the United States. Due to the disease’s prevalence, there has been extensive research done to try to find a cure. As a result, there have been many studies showing Vitamin K2 as an effective means to help patients re-strengthen their bones.

In one of these research studies, a large sample size of blood serum was collected in both Japanese and British women. They found that the Vitamin K2 content of Japanese women was nearly four times higher than that of British women. Even more interesting was that the Vitamin K2 content of each population was inversely proportional to the number of hip fractures. This was a strong indication that Vitamin K2 may reduce the risk of weakened bones.

Another study was conducted over 3 years in a double-blind fashion. The study was conducted with 325 postmenopausal women who received either a placebo or a daily dose of Vitamin K2. The researchers measured the bone mineral content and hip geometry for each patient. They concluded that Vitamin K2 helped maintain and strengthen bone mineral content and femoral neck width (bone thickness).

 

Kidney Health

A special filter system for your body

Kidneys are essential organs that help maintain a clean, balanced circulatory system. Some of its vital roles include maintaining acid/base homeostasis, regulating electrolyte concentration, maintaining blood pressure, filtering the blood to remove waste, and stimulating new red blood cell production.

When your kidneys begin to lose function (from pathogens, injury, toxins, etc.) this is called Kidney Disease. One of the first causes of death in Kidney Disease is due to cardiovascular ossification (calcium buildup in the arteries).

Researchers in a 2011 study suggested that Vitamin K2 could play an important role in Kidney Disease because it converts specific proteins that inhibit calcium buildup in the arteries and maintains proper mineralization processes. In another research article published in Nature, several scientists even suggest Vitamin K2 as a therapeutic intervention for extraosseous calcification in people with Kidney Disease.

In another independent study, scientists studied rats with poor kidney function. When these rats were supplemented with Vitamin K2, they found an increase in femoral/cortical bone strength and improved kidney function.

Liver Health

A Japanese study was conducted with hepatocellular carcinoma (liver cancer) in rats. When the rats with cancer were given perindopril in conjunction with Vitamin K2, there was a significant reduction in preneoplastic lesions compared to rats treated with just one or the other. This led the researchers to conclude that this could be a new chemo-preventative method against Liver Cancer.

These same scientists also ran a human clinical study. The study was with a 66-year-old woman with a dysplastic nodule that had an elevation of tumor markers. They treated her with oral administration of ACE-I and Vitamin K2, and after only one year, the nodule was completely gone.

Cancer

A Japanese study was conducted with hepatocellular carcinoma (liver cancer) in rats. When the rats with cancer were given perindopril in conjunction with Vitamin K2, there was a significant reduction in preneoplastic lesions compared to rats treated with just one or the other. This led the researchers to conclude that this could be a new chemo-preventative method against Liver Cancer.

Neurological Health

In 2012, a groundbreaking piece was published in the prestigious scientific journal called Science. The article revealed Vitamin K2 as a novel electron transporter, which is essential in proper mitochondrial and neurological functioning. The researchers go on to suggest that Vitamin K2 could be a possible treatment for mitochondrial diseases such as Parkinson’s disease and amyotrophic lateral sclerosis (ALS)

About Natto MK7™

Vesta’s NattoMK-7™ (Vitamin K2, also known as MK-7) is an all-natural product and highly bioavailable. Vitamin K is essential in proper bone mineralization and in regulating calcium levels within arteries, and it has gained much attention due to its highly efficacious nature.

Supplementation of Vitamin K has been shown to be very important in maintaining healthy bones and cardiovascular system. Of all the types of Vitamin K, Vitamin K2 (MK-7) derived from Natto has been shown to be the most effective and longer lasting benefits after supplementation due to its longer half-life in circulation.

Vesta provides all NATURAL and PURE MK-7 as demonstrated by 100% trans- isomer analysis. Competitor products with impure and poor quality MK7 contain too much of the cis- isomer typical of synthetic products.

Vesta has worked with the US Pharmacopeia (USP) to develop the MK7 monograph for Dietary Supplements. Vesta follows the USP 40 & 41 Dietary Supplement Monographs to confirm high quality MK7.

  • Greater than 95% pure menaquinone-7
  • 100% Trans-form – the most usable form for human consumption
  • Highly stable & Highly bioavailable
  • No Solvents / Additives / Preservatives, nonGMO, Free of Allergens
  • Clinically-proven to support bone & cardiovascular health
  • Highest purity crystals and highest strength mean less is needed for proper dosage in your custom supplement
  • Kosher Certified – Your assurance of purity
  • Halal Certified
  • Non-GMO
  • HACCP-certified manufacturing facility
  • Extremely competitive pricing

Vesta Ingredients is producing nattoMK-7™using an advanced CO2 extraction process. This supercritical extraction process uses high pressure and low temperatures for environmentally friendly manufacturing. This process also preserves the original active properties without any solvents while also producing a concentrated and pure extract for the most bioactive form of MK-7.

Physical Form Strength Carrier
Powder 10,000ppm (1.0%) Dicalcium Phosphate
Powder 5,000ppm (0.5%) Dicalcium Phosphate
Powder 2,000ppm (0.2%) Dicalcium Phosphate

Also available with Maltodextrin Carrier or Microencapsulated Formulation

Why Natto MK-7™ For Your Product?

Why Natto MK-7™ For Your Product?

About Vitamin K

About Vitamin K

Vitamin K is a class of fat-soluble vitamins. This essential vitamin exists naturally in foods such as leafy, green vegetables and soybeans, and it is vital for your body to properly regulate and activate important proteins such as clotting factors in the liver, Matrix GLA Proteins found in your arteries, and osteocalcin in bones.

Your body utilizes Vitamin K in two forms, Vitamin K1 (phylloquinone) and Vitamin K2 (menaquinones). Vitamin K1 helps blood coagulate/clot properly. Whereas Vitamin K2 helps reduce calcium plaque buildup in your arteries and guides calcium absorption to strengthen your bones. Several clinical studies show how Vitamin K2 serves to improve cardiovascular health while simultaneously increasing bone mineral density.

Vitamin K is a class of fat-soluble vitamins. This essential vitamin exists naturally in foods such as leafy, green vegetables and soybeans, and it is vital for your body to properly regulate and activate important proteins such as clotting factors in the liver, Matrix GLA Proteins found in your arteries, and osteocalcin in bones.

Your body utilizes Vitamin K in two forms, Vitamin K1 (phylloquinone) and Vitamin K2 (menaquinones). Vitamin K1 helps blood coagulate/clot properly. Whereas Vitamin K2 helps reduce calcium plaque buildup in your arteries and guides calcium absorption to strengthen your bones. Several clinical studies show how Vitamin K2 serves to improve cardiovascular health while simultaneously increasing bone mineral density.

Vitamin K2 is a subclass of fat-soluble Vitamin K. Vitamin K1 is referred to as phylloquinone while Vitamin K2 is referred to as menaquinone (or MK for short). Within Vitamin K2, there are different variants ranging from MK-4 to MK-12, the numbers indicating the length of isoprenoid, carbon side chain. The two naturally occurring forms are MK-4 and MK-7.

Vitamin K2 (MK-7) is unique in that it has been shown to be more bioavailable and has a longer half-life in the bloodstream after oral intake, thus providing its benefits for a longer period.

Through aging, malnutrition or disease, bones become weak and brittle while calcium builds up to harden and block off arteries. Healthy bones and clearer arteries can be reestablished with proper diet, exercise, and supplementing Vitamin K2 (MK-7).

Vitamin K2 helps take calcium from hardening arteries to strengthening bones!

A Brief History of Vitamin K

Vitamin K was first discovered in 1929 by Henrik Dam who was studying the role of cholesterol by depriving chickens of cholesterol in their diet. He subsequently observed a particular vitamin extract from these chickens in relation to blood coagulation. The actual K from Vitamin K comes from the German name, Koagulationsvitamin (in English: Coagulation Vitamin). Subsequently, both Henrik Dam and Edward Doisy were awarded the Nobel Prize in 1943 for their important roles of discovering Vitamin K and its structure. Since then, over 15,000 research articles have been published, by countless scientists around the world, concerning the great health benefits and essential functions of Vitamin K.

Vitamin K2 (MK-7) compared to Vitamin K1

Dr. Schurgers and colleagues conducted a clinical study comparing Vitamin K2 (MK-7) to Vitamin K1 and found that MK-7 had a much longer half-life. Thus, the study indicated a much more positive health benefit of supplementing Vitamin K2 over Vitamin K1 due to the prolonged efficacy of Vitamin K2 (MK-7) in the circulatory system.


All Natural Vitamin K2: MK-7 compared to Synthetic Vitamin K2

Vitamin K2: MK-7 does not display toxicity, and does not concentrate in excess amounts in the liver, unlike other synthetic Vitamin K2. Simply put, MK-7 may help promote a healthy cardiovascular system and maintain healthy bones, joints, and arteries through all-natural means.

MK-7 compared to MK-4

When comparing Vitamin K2: MK-4 versus MK-7, the currently accepted recommendation of daily intake requires a much lower intake of MK-7 compared to MK-4 for the same effects. Recommended dosage of MK-4 is ~45,000 micrograms/day whereas MK-7 is ~45 micrograms/day. That is a 1000-fold less requirement of MK-7 compared to MK-4! Not only is less more in the case of MK-7 compared to MK-4 but both MK-7 absorption and the lasting benefits in circulation are far superior to MK-4. Much of this reasoning has been attributed to MK-7’s proper carbon side chain length. The proper carbon length of MK-7 allows for longer-lasting and more efficacious Vitamin K2 compared to MK-4. This makes MK-7 more bioavailable and appealing in supplementing our diets.

How Calcium is Absorbed and Incorporated

For the longest time, conventional wisdom suggested that whenever consuming calcium, Vitamin D3 is essential. This is certainly true because Vitamin D3 aids in absorbing calcium from the digestive tract into the arteries, but in light of recent research and studies, we now realize that this is only half the story. Vitamin K2 has been shown to be equally important in preventing calcium build-up in arteries and transporting it into bones instead.

Vitamin K2 acts within many different organs in the body to maintain the proper functions of vital proteins that depend on Vitamin K for its activation. Within your bones, a Vitamin K2 activated protein called Osteocalcin functions to incorporate calcium hydroxyapatite into bones to build them up and keep them strong. Vitamin K2 also functions in your blood vessels by interacting with Matrix Gla Protein to keep calcium from accumulating in your arteries.

Even now we can see that just about every product having to do with calcium is supplemented with Vitamin D3 (i.e. dairy products, supplements, etc.) but the same cannot be said about Vitamin K2. Because of ample amounts of Vitamin D3 and Calcium in your diet but lack of Vitamin K2, calcium is successfully absorbed into your bloodstream but isn’t incorporated into your bones. As a result, calcium plaques begin to form and harden along the sides of arteries, while simultaneously your bones begin to weaken due to lack of calcium.

Vitamin K2 (MK-7) helps keep calcium from hardening and blocking arteries while redirecting calcium to maintain bone strength at the same time.

 

A Growing Problem

Vitamin K deficiency is currently a major problem due to the lack of a properly balanced diet. According to the University of Maryland Medical Center, Vitamin K deficiency can also be caused by diseases such as biliary disease, cystic fibrosis, celiac disease, liver disease, and Crohn’s disease, and they recommend that patients supplement their diets. Deficiency in Vitamin K has been linked to osteoporosis, fractures, and improper calcium balance in arteries and veins. Thus, it is very important that we supplement our diets with the proper amount of Vitamin K.

When comparing Vitamin K2: MK-4 versus MK-7, the currently accepted recommendation of daily intake requires a much lower intake of MK-7 compared to MK-4 for the same effects. Recommended dosage of MK-4 is ~45,000 micrograms/day whereas MK-7 is ~45 micrograms/day. That is a 1000-fold less requirement of MK-7 compared to MK-4! Not only is less in the case of MK-7 compared to MK-4, but both MK-7 absorption and the lasting benefits in circulation are far superior to MK-4. Much of this reasoning has been attributed to MK-7’s proper carbon side chain length. The proper carbon length of MK-7 allows for longer-lasting and more efficacious Vitamin K2 compared to MK-4. This makes MK-7 more bioavailable and appealing in supplementing our diets. Kaneki, et al 2001

Researchers found a significantly higher incidence of hip fractures in the UK compared to that of women in Japan. They found that Women in Japan had much higher levels of MK-7, which correlated with the consumption of Natto.

Location n PK (ng/mL) MK-7 (ng/mL) Age
United Kingdom 31 0.497 ±0.537 0.371 ±0.204 58.5 ±9.4
Hiroshima 25 0.741 ±0.581 1.221 ±1.848 57.2 ±3.3
Tokyo 49 0.727 ±0.461 5.268 ±6.132 67.4 ±8.3

They further found how Natto consumption led to an increase in MK-7. This helped explained why women in the UK had more frail bones leading to hip fractures compared to women of Japan. Women of Japan were benefiting from the MK-7 in Natto that helped their bones stay strong.

Vitamin K2 is highly bioavailable and lasts a long time in the blood system

 

Natto MK-7™ was named after a long-held traditional Japanese dish called Natto. Natto is made through the fermentation of soybeans and has been a staple of the Japanese diet for centuries. Natto has traditionally been eaten for breakfast with rice and other dishes. Through centuries of regular Natto consumption, many people started to realize the major health benefits associated, such as decreased blood pressure, reduced incidence of osteoporosis, etc. A group from Kinki Medical School definitively showed how intake of Natto in postmenopausal women caused a reduction in bone loss. Subsequent clinical and population-based studies found that these benefits were largely attributed to the fact that Natto was full of Vitamin K2.

The fermentation process of Natto is facilitated by Bacillus subtilis. Interestingly, Bacillus subtilis exists naturally and produces MK-7 (Vitamin K2) as a passive byproduct. With over 1000 µg of Vitamin K2 per serving of Natto, and 90% of that being MK-7, it becomes obvious as to where the great health benefits were coming from.

Even with its greatly indicated health benefits, Natto remains unknown in many parts of the world. Due to its slimy texture and unique smell, many people find it very unappetizing. Fortunately, Vesta Ingredients, Inc. nattoMK7 offers the great health benefits of Natto by extracting Vitamin K2: MK-7 directly from Bacillus subtilis. Thanks to engineering from our top scientists and an advanced filtration process, our Vitamin K2 (MK-7) is of the highest quality. Our product is completely all-natural, allergen-free, non-GMO, and even Kosher Certified.

MK7

Vesta Natto MK-7™ is Vitamin K2 MK-7, also known as Menaquinone-7. MK-7 is a highly bioavailable extract of “natto” which is a traditional Asian soy-food dish. The Vitamin K2 form of MK-7 is absorbed better than the Vitamin K1 form, which is more commonly found in other food products.

Natto MK-7™ functions in the carboxylation and binding of calcium to specific bone proteins. Research shows that MK-7 regulates calcium in the arteries as well. Thus, Natto MK-7™ ultimately supports both circulatory and skeletal health at the same time.

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Product Details

Why Natto MK-7™ For Your Product?

MK-7 regulates calcium through an amino acid that is part of the matrix Gla protein (a calcium-regulating protein), which is dependent on MK-7 to function properly. If the protein does not contain enough MK-7, it will not be able to retain calcium through carboxylation. Without MK-7, the calcium does not get directed to the areas where it is needed, such as the bones, and instead calcium moves out into the bloodstream and deposits in arteries and other soft tissue. MK-7 ensures that the calcium is directed and retained in the bones at normal, healthy levels.

  • Appearance: Powder
  • Odor / Taste: Characteristic
  • Dose: 45-160 mcg / daily
  • Store in a cool dry place
  • Do not freeze
  • Keep away from strong direct light
  • Package Unit: 1-5 kg
  • Dietary supplement
  • Capsules / Tablets / Softgels / Powder

References

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  3. Steven M. Plaza, ND, LAc, and Davis W. Lamson, MS, ND. Vitamin K2 in Bone Metabolism and Osteoporosis. Altern Med Rev 2005;10(1):24-35
  4. Iwamoto,, Ichiro, and Et. Al. “A Longitudinal Study of the Effect of Vitamin K2 on Bone Mineral Density in Postmenopausal Women a Comparative Study with Vitamin D3 and Estrogen–progestin Therapy.” The Official Journal of the European Menopause and Andropause Society, 30 Jan. 2009.
  5. Schurgers LJ, Teunissen KJ, Hamulyak K, Knapen MH, Vik H, Vermeer C., Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7., Blood. 2007 Apr 15;109(8):3279-83.
  6. Steven M. Plaza, ND, LAc, and Davis W. Lamson, MS, ND. Vitamin K2 in Bone Metabolism and Osteoporosis. Altern Med Rev 2005;10(1):24-35
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  38. Tsukamoto Y, et al. Intake of fermented soybean (natto) increases circulating vitamin K2 (menaquinone-7) and gamma-carboxylated osteocalcin cocentration in normal individuals. Journal Bone Mineral Metabolism. 2000;18(4):216-22.
  39. “Rhéaume-Bleue, Kate. “Vitamin K2 and the Calcium Paradox” John Wiley & Sons Canada, Ltd., 2012, p. 66-67
  40. Elder SJ, Haytowitz DB, Howe J, Peterson JW, Booth SL (January 2006). “Vitamin k contents of meat, dairy, and fast food in the U.S. Diet”. J. Agric. Food Chem. 54 (2): 463–7. doi:10.1021/jf052400h. PMID 16417305.
  41. Hosking, Richard (1995). A Dictionary of Japanese Food – Ingredients and Culture. Tuttle. p. 106. ISBN 0-8048-2042-2.
  42. Buerk, Roland (11 March 2010). “Japan opens 98th national airport in Ibaraki”. BBC News. Retrieved 25 December 2012. “… natto, a fermented soy bean dish that many consider an acquired taste.”
  43. Katz, Sandor Ellix (2012). The Art of Fermentation: An In-Depth Exploration of Essential Concepts and Processes from Around the World. Chelsea Green Publishing. pp. 328–329. ISBN 978-1603582865. “Natto is a Japanese soy ferment that produces a slimy, mucilagenous coating on the beans, something like okra. […] The flavor of natto carries notes of ammonia (like some cheeses or overripe tempeh), which gets stronger as it ferments longer.”

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